These novel markets accept unsolicited submissions. The links below lead to submission guidelines or, if these are not available, to the publishers webpage.

Aardwolf Press
Submission Guidelines

Baen Books
Submission Guidelines

BFS Publications
Submission Guidelines

DAW Books
Submission Guidelines

EDGE Science Fiction and Fantasy Publishing
Submissions Guidelines

ROC Books
Newsletter
Note: Roc Books strongly discourages unsolicited submissions, but they do accept them . . . for now.

Tom Doherty Associates LLC
Submission Guidelines

If you learn of any more science fiction or fantasy novel publishers that accept unsolicited submissions, please contact me and let me know. Thanks.